Search results for "pathology [Otolithic Membrane]"

Exosomal HSP60: a potentially useful biomarker for diagnosis, assessing prognosis, and monitoring response to treatment.

2017

Introduction: Cell-to-cell communication is imperative for life and it is mediated by sending and receiving information via the secretion and subsequent receptor-mediated detection of biological molecules. Exosomes (EXs) secreted from cells to the extracellular environment play an important role in intercellular communication in normal and pathological conditions. Areas covered: New evidence indicates that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment. The exosomal heat shock protein 60 (HSP60) is very likely a key player in intercellular cross-talk, particularly during the progress of diseases, such as cancer. Many studies have fo…

Histiocitosis de células de Langerhans de partes blandas y hueso con células gigantes multinucleadas y mutación BRAF V600E

2021

Resumen La histiocitosis de celulas de Langerhans (HCL) es una enfermedad heterogenea caracterizada por una proliferacion de celulas de Langerhans y la presencia de la mutacion BRAF en aproximadamente la mitad de los casos. La afectacion osea es comun pero la presencia de grandes masas en partes blandas no es habitual. Reportamos un caso de un paciente pediatrico que comenzo con una gran masa tumoral en hueso iliaco izquierdo con extension a partes blandas adyacentes. La tomografia axial computarizada mostraba una lesion osteolitica con gran extension a partes blandas. Se realizo una biopsia quirurgica por curetaje y el diagnostico histopatologico fue de HCL con positividad intensa para CD1…

Analysis of metacarpal V fractures of an interdisciplinary emergency room of an urban German hospital from a forensic viewpoint

2015

Metacarpal V fractures, especially metacarpal neck fractures, are known to the forensic society as a ‘boxer’s fracture’ and are described as being mostly caused by punching an immovable or firm object with force with a closed fist. To our knowledge there is no larger study that examines these fractures under forensic considerations of epidemiology. Our study includes the analysis of metacarpal V fractures in an interdisciplinary, academic and university-affiliated emergency department of an urban hospital over a period of three years. Emergency data sheets were systematically analysed and X-rays evaluated. The results were compared with the existing literature.

Inhibition of succinate oxidation by the herbicide UKJ72J

1985

Abstract The inhibitory activity of the herbicide UKJ72J on succinate oxidation in mitochondria from various plant species was studied. In monocotyledons (Gramineae: wheat, oat, maize; Liliaceae: onion, leek) succinate oxidation was affected only at high concentrations. Among dicotyledons widely differing sensitivities were found: in Solanaceae (tomato, potato, tobacco), Leguminosae (mung bean, soybean) and Compositae (sunflower) I 50 concentrations for UKJ72J inhibition were below 55 μM. In Cruciferae (turnip, cauliflowers Chenopodiaceae (lambsquarter, beetroot) and Compositae (endive) I 50 were between 100 and 250 μM, whereas in Rosaceae (apple, pear) and Umbelliferae (carrot, fennel) I 5…

Metabolic detoxification: implications for thresholds.

2000

The fact that chemical carcinogenesis involves single, isolated, essentially irreversible molecular events as discrete steps, several of which must occur in a row to finally culminate in the development of a malignancy, rather suggests that an absolute threshold for chemical carcinogens may not exist. However, practical thresholds may exist due to saturable pathways involved in the metabolic processing, especially in the metabolic inactivation, of such compounds. An important example for such a pathway is the enzymatic hydrolysis of epoxides via epoxide hydrolases, a group of enzymes for which the catalytic mechanism has recently been established. These enzymes convert their substrates via…

Latent Profile Approach to Duration of Stalking

2010

Stalking behavior and victim-stalker relationship are often the principal known factors in a stalking case. Thus, they are of great importance when trying to identify factors contributing to stalking duration. The present study aims to identify distinct subgroups of stalking victims based on measures of behavioral stalking dimensions. These victim subgroups, stalking dimensions, and victim-stalker relationship are examined in relation to stalking duration. Using a sample of 137 university students, latent profile analysis (LPA) revealed five distinct victim subgroups based on stalker behavior dimensions: surveillance, low-profile, social lurker, wide scope, and baseline stalkers. The subgro…

The role of moral disengagement and cognitive distortions toward children among sex offenders

2018

This study investigated the individual and social characteristics, moral disengagement strategies and cognitive distortions toward children among 120 sex offenders in Italian jails. A semistructured interview was administered to collect data about family, social and medical histories, utilizing the Moral Disengagement Scale and the Hanson Sex Attitude Questionnaire. Results showed that sex offenders with sexual abuse trauma in their past had higher scores of moral disengagement and cognitive distortion toward children than sex offenders without sexual abuse trauma. In particular, the highest levels of moral disengagement, cognitive distortions related to children as sexual objects and sexua…

Molecular characterization of Treponema pallidum subsp. pallidum in Switzerland and France with a new multilocus sequence typing scheme

2018

Syphilis is an important public health problem and an increasing incidence has been noted in recent years. Characterization of strain diversity through molecular data plays a critical role in the epidemiological understanding of this re-emergence. We here propose a new high-resolution multilocus sequence typing (MLST) scheme for Treponema pallidum subsp. pallidum (TPA). We analyzed 30 complete and draft TPA genomes obtained directly from clinical samples or from rabbit propagated strains to identify suitable typing loci and tested the new scheme on 120 clinical samples collected in Switzerland and France. Our analyses yielded three loci with high discriminatory power: TP0136, TP0548, and TP…

Attitudes of Patients With Skin Tumors During the COVID-19 Pandemic

2021

Identity profiles and digital engagement among Finnish high school students

2018

Developing a stable personal identity is considered a more precarious task in today’s society than hitherto. Skilful digital engagement may, however, constitute a valuable asset in necessary identity exploration and commitment. Applying a person-oriented approach, we examined for the first time how identity profiles are associated with digital engagement, operationalized as digital competence, gaming seriousness, type of internet activity and excessive ICT use. After controlling for gender, life satisfaction and parental SES, this study of a Finnish high school sample (N = 932) revealed that adolescents with future commitments and some exploration of options (achievement, searching moratori…